New York Times. Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects.
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Cialis can help achieve an erection when sexual stimulation occurs. Last updated on Jan 12, Call your doctor for medical advice about side effects.
Tadalafil is an annulated 2,5-diketopiperazine. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension. Gilman Karen N. Pharmaceutical Press.
Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 enzyme. Some medicines can cause unwanted or dangerous effects when used with Cialis. Pharmaceutical Press.
The presence of other drugs which induce this system can shorten tadalafil half-life and reduce serum levels, and hence efficacy, of the drug. Medically reviewed by Sanjai Sinha, MD.
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