Synthesis of sildenafil citrate

Preparation of 5-[2-ethoxy 4-methylpiperazinylsulfonyl phenyl]methylethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidinone sildenafil ethyl analogue, 4a. Thereafter, the reaction mixture was cooled and evaporated under vacuum.

Compound 14c was prepared from compound 13c. Julie V. Preparation of 5- 5-chlorosulfonylethoxyphenyl methylbutyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidinone 3b. Compound 2c was prepared from compound 14c as a white solid.

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Process for Preparation of 5- 2-Ethoxy 4-methylpiperazinyl sulfonyl phenyl isobutylmethyl-1H-pyrazolo[4,3- d ]pyrimidin 6H -one Sildenafil Citrate Impurity Application No. Raghava Reddy. The reaction was cooled to room temperature before it was poured onto ice, then filtration and drying gave 4-nitrocarboxylic acid 11a — synthesis of sildenafil citrate as a white solid.

Authors also thank the Analytical Research Department for their valuable contribution to this work. Ghozlan S.

Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues. Theory and Practice.

Results and Discussion Chlorosulfonation is a two-stage process: External link. Synthesis technology of sildenafil analogues. Compound 13a was prepared from compound 12a.

Compound 11b was prepared from 10b as a white solid. Scheme 3.

Sildenafil citrate 1 is a selective inhibitor of cyclic guanosine monophosphate cGMP -specific phosphodiesterase type 5 PDE5which synthesis of sildenafil citrate responsible for the degradation of cGMP in levitra shop germany corpus cavernosum. Dichloromethane solution containing compound 3a was used as such in the next step. Shopping Cart Your cart is empty Checkout.

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